Top 50 Biotechnology Startup Investors in Italy in October 2023

Portfolio highlights

• Crescendo Biologics — Crescendo Biologics is a new Cambridge-based company whose vision is to deliver next-generation antibody therapeutics based on novel class-leading platforms.The focus of the company is on developing platforms that will address key issues in generating high-affinity, soluble, human VH antibody fragments. These are the smallest fragments thatretain antibody binding, and have many desirable properties as potential therapeutics. Crescendo will then utilise these platforms for product development of in-house targets or in partnership with other companies.
• Sitryx Therapeutics — Sitryx is a biopharmaceutical company focused on regulating cell metabolism to develop first-in-class disease modifying therapeutics in immuno-oncology and immuno-inflammation. The company was co-founded by a team of world-leading scientists from the United States and Europe who have contributed significantly to the field of immunometabolism.Sitryx was founded in 2018 with seed funding from SV Health Investors and raised $30 million Series A funding from an international syndicate of specialist investors including SV Health Investors, Sofinnova Partners, Longwood Fund and GSK. The company has a pipeline of projects at multiple stages of drug discovery. Sitryx is headquartered in Oxford, UK.
• Tenpoint Therapeutics — Tenpoint Therapeutics is a biotechnology company pursuing vision-restoring engineered cell-based therapeutics.

Portfolio highlights

• WORA — Wora is integrated with the main e-commerce platforms. For in-store purchases or via alternative channels (e.g., Instagram, WhatsApp, telephone), they make their app available to retailers to be able to send their requests easily.
• Viceversa — Viceversa provides capital to European digital businesses to support companies in sustainable and ethical growth. The company was founded in 2021 and has locations in Milan and Dublin.
• Resalis Therapeutics — Resalis Therapeutics sviluppa un farmaco in grado di inibire un micro-RNA per il trattamento di alcune malattie metaboliche

Portfolio highlights

• NEWTWEN — We develop software that generates real-time embedded digital twin solutions for model predictive control and diagnostics of electromechanical systems, enhancing performance, longevity, and reliability. In essence, our toolchain creates a precise digital replica of a physical device, such as an electric motor or generator, in order to accuratelymodel the electrodynamic and thermodynamic behavior of the system across a wide range of operating conditions. We then apply our proprietary mathematical approach to exponentially reduce the computational complexity of this model—so much so, in fact, that our digital twin can be integrated into the device itself to compute in real-time, “on-chip,” as part of an amazingly fast and accurate firmware solution. By accurately predicting temperatures and other critical system parameters thousands of times per second, our Digital Twin On-Chip solutions not only provide unprecedented insight for real-time control techniques to enhance system performance, but also pave the way for data-as-a-service capabilities such as predictive maintenance, monitoring of component aging, and anomaly detection.
• Coverzen — The digital office of insurers
• Sibylla Biotech — Sibylla Biotech developed small molecule folding interfering degraders (FIDs) that can address a range of therapeutic areas.

Portfolio highlights

• KLISBio — KLISBio is a medtech company currently developing a variety of regenerative medicine implantable products leveraging the power of silk fibroin to promote an endogenous repair of human soft tissues.
• ENTEROME — We are a clinical stage biopharmaceutical company developing novel drugs to transform human health based on our unique ability to de-code molecular interactions in the gut microbiome.
• WISE — WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

Portfolio highlights

• Easy Rain — We are Easyrain. Continuous innovation runs in our blood.With our expertise, we develop, simulate, and test solutions, launching our ideas into production. We exploit the basic laws of physics to engineer a tangible solution!
• Sibylla Biotech — Sibylla Biotech developed small molecule folding interfering degraders (FIDs) that can address a range of therapeutic areas.
• Alia Therapeutics — Alia Therapeutics is developing next-generation gene-editing medicines to cure rare genetic diseases.

Portfolio highlights

• GreenBone Ortho — GreenBone Ortho was founded in Faenzato offer advanced and innovative solutions in the field of orthopaedics and bone regeneration, using the Rattan wood.
• Renovacor — Renovacor is a preclinical‑stage biopharmaceutical company focused on developing transformative gene therapy‑based treatments for cardiovascular disease.Renovacor’s lead program is a recombinant adeno-associated virus (AAV)‑based gene therapy for patients suffering from dilated cardiomyopathy (DCM) due to mutations in the Bcl2‑associatedathanogene 3 (BAG3) gene.Dilated cardiomyopathy is a condition affecting over 3 million patients in the US and growing steadily. Many patients develop DCM due to ischemic heart disease. Recently subpopulations have been identified that develop DCM due to mutations in specific genes that have been shown to result in the development of DCM. One of these specific genes is the BAG3 gene. The prevalence of disease‑causing BAG3 haploinsufficiency is estimated at approximately 35,000 individuals in the United States, representing an orphan disease by FDA guidelines. It is estimated a similar number of DCM patients with BAG3 mutations exist in Europe. These patients are typically younger and progress to end-stage heart failure sooner than patients with ischemic heart disease. Currently, DCM patients with a BAG3 mutation are treated with standard of care for heart failure. Despite improvements in pharmacotherapy and care, the five‑year survival of a patient with DCM is only 50%. The development of a BAG3 gene replacement therapy for patients with DCM that carry BAG3 mutations could potentially prevent the progression of disease in this otherwise healthy population of young adults.
• BetaGlue Technologies — BetaGlue Technologies engage in the research and offers anticancer products.

Portfolio highlights

• Reefilla — Reefilla EV charging services: recharge your car anywhere, anytime
• Endostart — Endostart development and manufacturing of a new generation medical devices for gastrointestinal endoscopy.
• Neuron Guard — Neuron Guard, recognized as the best European startup in HEALTH category (Startup Europe Awards - SEUA 2017), is developing a life-saving medical device that aims to become the standard of care for Targeted Temperature Management (TTM) therapy. Every 7 seconds around the world a person suffers of Acute Brain Damage because of CardiovascularDiseases (CVD) and Traumatic Brain Injury (TBI). They are the most costly and prevalent killers in the last 15 years (15 million deaths by CVD in 2015), and the leading cause of disability (the global incidence rate of TBI is 200 per 100k people per year). WHO estimated a global expenditure of $ 330 billion in 2015, but it is going to increase sharply: $ 4 trillion in 2025 - including premature death, disability, and health care costs - just for CVD in LMICs. Temperature is a vital body parameter. It regulates all cellular functions so its management is essential for the good outcome of patients in several medical conditions such as cardiac arrest, stroke, traumatic brain injury, neuro and cardiac surgery, epilepsy, migraine and oncology. Regulating body temperature at a desired level makes all other treatments more effective. The most modern medical approach is the target temperature management, where physicians try to maintain the most favourable temperature for the patient for up to 24-36 hours, preventing excessive warming (fever) or cooling.Our device is a targeted temperature management system composed by a THERAPEUTIC COLLAR POWERED BY A SMART CONTROL UNIT (the size of a small briefcase). The collar transforms the neck into a natural heat exchanger exploiting several physiological and anatomical characteristics of the human body. It is quicker to act on brain tissue but can also function as total body temperature adjusting device if required. A disposable protective shield makes cleaning the collar after each use simple while featuring an optimal safety profile both in term of pathogens and allergens. The control unit collects all the data of the treatment and transmits them to the Emergency Response System. Our mission is to improve the safety of patients on the roadside, at home or in the workplace, and to reduce the costs of chronic care. In fact, Neuron Guard aims to be the only device that can be used in every circumstance, inside and outside the hospital, and allow the user to fully manage the temperature of the patient warming and cooling as necessary. Our vision is to have a Neuron Guard kit in every public place just like the Automatic External Defibrillator (AED) to empower bystanders to immediately react in case of emergency. Under this perspective our device becomes a connected-intelligent platform that takes care of the patient, connects the scene with the Emergency Response System transmitting vital data to improve the readiness and effectiveness of professional intervention.The device is patented in Italy, USA and China. We have made several prototypes in collaboration with Italian and English companies, such as Tecno Elettra Impianti and TWI, tested it in laboratory and published the experimental results on the NeuroCritical Care Journal. We have also conducted a GAP Analysis with another English consulting firm (CDP) and we are testing the human prototype internally. We are seeking to raise 2.5M€ to complete the pre-industrialization, with design and construction of the human device for the pilot trial, finalized the regulatory clearance and launch it into the market in 2019.

Portfolio highlights

• Cogisen — Cogisen develops artificial intelligence solutions. It offers SENCOGI, an eye-tracking software for smartphones/mobile phones. Chiara Passacantilli and Christiaan Erik Rijnders founded Cogisen in 2009. Its headquarters is in Naples in Italy.
• Directa Plus — Directa Plus is a nanotechnology company, manufactures nanoparticles.
• Glomeria Therapeutics — Glomeria Therapeutics researches, develops, and markets new medical devices for the treatment of serious diseases in the nephrological area. It offers DesmoPD, peritoneal dialysis connection system; SmartPD, an automated management device for peritoneal dialysis solutions to be instilled in peritoneum; and solutions for peritoneal dialysis.Andrea Zanella founded Glomeria Therapeutics in 2010. Its headquarters is in Chieti in Italy.

Portfolio highlights

• treet — Treet helps brands launch fully-branded recommerce sites where customers can buy & sell items from each other.
• Newronika — Newronika restores brain and body functions with innovative technologies. We translate our deep knowledge on biosignal decoding into clinical practice, with the aim of improving treatments, health, and wellness. With our revolutionary brain devices, the patient receives the right stimulation at the right moment, thus becoming able to perform normaldaily activities and improve quality of life. Newronika is the spin-off company of two leading research institutions in Italy, the Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Hospital and the University of Milan. ​ Newronika comprises a multidisciplinary team formed from Neuroscience research groups and involves scientists with expertise in neurophysiology, neurology, biomedical engineering, neuropsychology, bioinformatics, and biotechnologies.
• WISE — WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

Portfolio highlights

• Ecomate — The ESG Rating platform for every company
• BigProfiles — A deep understanding of customers let a company tailor marketing campaigns and CRM strategies, but companies have only basic data about customers (e.g. gender or age). External data sources like Social Networks, Public Registries and Socio-Demographic data contain rich information about billions of people, like job titles, levels of education,interests and habits.BigProfiles is a Customer Intelligence SAAS that leverages external information about persons to enrich customer profiling: it can profile a company's customers with previously unknown information about them. Thanks to its Identity Resolution algorithm (the result of a PHD), it identifies a person’s information scattered among external sources.Through this technology, BigProfiles provides customer base analytics and behavior predictions: using Artificial Intelligence on enriched profiles allows to predict churn, fraud and willingness to buy.
• Codemotion — Codemotion is the ecosystem devoted to innovation, focused on developers and coding, open to all programming languages and technologies. Pioneering spirits, it scout the future to deliver a first class experience to our people. Codemotion is one of the biggest tech-conferences in Europe, with an international network of 30.000 developers and 350speakers coming from all over the world and from the most important IT realities.Codemotion draw in its main conferences, thousands of attendees eager to discuss about hottest topics: it tailor for them disruptive proposals ranging from mobile to UX, develops, cloud, big data, gamedev, security, methods, languages, web, Internet of things. Codemotion is also a startup, providing a bunch of services and activities, for personal and business customers.

Portfolio highlights

• NeoPhore — NeoPhore targets the dynamics of cancer neoantigen evolution and makes effective medicines that will become a key part of the next-generation of cancer immunotherapies.
• Repron Therapeutics — Repron Therapeutics provides treatments for solid tumor cases where radical excision is not possible and metastasis or recurrence is extremely likely.
• Resalis Therapeutics — Resalis Therapeutics sviluppa un farmaco in grado di inibire un micro-RNA per il trattamento di alcune malattie metaboliche

Portfolio highlights

• Largix — Largix is the first company to develop and commercially produce 3D Robotic Printers for real production processes. We have invented the "Cold 3D Printing®" technology that makes 3DP possible for real industrial production. Largix uses the most common thermoplastic polymers: Polypropylene and Polyethylene, polymers that nobody else iscapable of printing.
• TextYess — Increase your eCommerce Retention with a Frictionless Experience.
• Electra Vehicles — Control, Analyze, & Design Innovative Battery Packs using Electra Vehicles' EVE-Ai 360 Adaptive Controls and Analytics and EnPower Design.

Portfolio highlights

• Picosats — PicoSaTs envisages a new generation of telecommunication systems for space applications dedicated to CubeSat pico-satellites. The key technologies at the core of this system are a software defined radio and a highly directive and configurable antenna, operating at higher frequencies (Ka band), and providing very high data rates.
• Leaf Space — Leaf Space aims to become a global leading service provider in the new, emerging microsatellite market by developing a technology platform providing all basic services required by microsatellite operators.
• Energy Dome — Energy Dome | Groundbreaking Long Duration Energy Storage. Using CO2 against climate change. Our Technology enables to store renewable energy efficiently.

Portfolio highlights

• i-TES srl — i-TES is providing consulting and assistance. They reduce energy waste and optimism the management of the system with the i-TES PCM thermal coil. They provide services for the thermal accumulator, including assistance, maintenance, consulting, research, and development. They provide research and development activities in the field of thermalstorage with innovative materials.
• Planckian — Charging the future by powering energy with science We explore frontiers of energy science by developing quantum...
• BeDimensional — We produce graphene and others two-dimensional materials (2D) with few atomic layers. Find out more.

Portfolio highlights

• CyLock — CyLock anti-hacker is a software designed to defend systems from hacker attacks, identifying weaknesses in their systems and websites, and providing information to address vulnerabilities used by the cybercriminal to access their computers. Through CyLock's Anti-Hacker system, small and medium-sized businesses will be able to test theirdigital defences to identify and eliminate vulnerabilities in websites, e-commerce sites, apps, e-mails, information systems, corporate networks, servers, and IoT. Companies that do not periodically test their digital tools and their staff skills are more exposed to cyber attacks, which turn into business interruptions, document loss, e-commerce, and online payments breakdown.
• Medicud — Medicud develops a device for treating wounds with negative pressure dressing.
• Rocky — Grow your mindset with the AI coaching chat in just 5 minutes of daily self-improvement sessions to be truly successful.

Portfolio highlights

• Sibylla Biotech — Sibylla Biotech developed small molecule folding interfering degraders (FIDs) that can address a range of therapeutic areas.
• Roca Therapeutics — Roca Therapeutics focuses on the research and development of small medicines to treat severe, life-threatening diseases brought on by hypervascularization and the immunosuppression produced by macrophages M2.
• Domain Therapeutics — Domain Therapeutics is a biopharmaceutical company focused on GPCR in immuno-oncology. Discover more than you think on our innovative cancer treatments tackling GPCR mediated-immunosuppression

Portfolio highlights

• MgShell — MgShell offers intraocular devices for the treatment of age-related macular degeneration and other ocular diseases. Their technology is the only technical solution capable of replicating current clinical practice with a single injection and releasing the same therapeutic drug doses at predetermined periods, autonomously and without surgicalprocedures.
• CaSRevolution — A novel disease-modifying approach against neurodegeneration
• Metis Precision Medicine — Metis Precision Medicine is a B-Corp founded with the vision of bringing powerful cancer therapies to patients in need. Metis owns the intellectual property of a suite of anti-Met monoclonal antibodies (mAbs), with different and unique mechanisms of action, and is currently seeking investors, biotech or pharmaceutical companies interested inacquiring the relevant platform technology on a global basis.

Portfolio highlights

• Ecopol — The Ecopol's PVA water-soluble film technology is the world leading solution in packaging applications, such as detergents, agrochemicals, etc.
• Edison Spa — Edison S.p.A is an energy company in the field of electricity and natural gas.
• Goglio Group — Goglio Group produces full trademark food packaging.

Portfolio highlights

• AvoMD — AvoMD is reimagining clinical decision support with interactive point-of-care software, available standalone and via EHR integrations, and seamless content building tools.
• Medwise.ai — Medwise.ai is the Google for doctors.
• Pear Suite — Pear Suite enables anyone—community health workers, other healthcare staff, and volunteers—to assess and address the social drivers of health for older adults in a scalable, cost-effective, and person-centered way.

Portfolio highlights

• CellPly — Cellply is a life-science company focused on developing next-generation analytical tools enabling a deep characterization of cancer immunotherapies, cell therapies and cell-based biotherapeutics. The company aims to support the development of novel cancer immunotherapies by accelerating R&D, automating the quality control and advancing theability to monitor the clinical response to these treatments.Through the use of proprietary microfluidic technologies with Co-Culture Array technology, highly-automated analytical instruments and AI-powered image and data analytics, Cellply products define the function of the immune system one cell at a time, combining functional data with other multiplex data and providing unprecedented single-cell analytical solutions.
• Test1 soultions — Test1 Solutions is an oil absorbent technique for hydrocarbons and their derivatives. They serve environmental clean up, oil spill clean up, hydrocarbon spills, geennovation, open cell oleophilic polyurethane foam with a hydrophobic effect, and hydrocarbon spills on water and land.
• Comptek Solutions — Comptek Solutions' novel passivation technology - Kontrox - promotes surface crystalline oxide reconstructions on the surface of the III-V compound semiconductor materials, enabling unprecedented efficiency of devices and a significant reduction in manufacturing costs

Portfolio highlights

• Newronika — Newronika restores brain and body functions with innovative technologies. We translate our deep knowledge on biosignal decoding into clinical practice, with the aim of improving treatments, health, and wellness. With our revolutionary brain devices, the patient receives the right stimulation at the right moment, thus becoming able to perform normaldaily activities and improve quality of life. Newronika is the spin-off company of two leading research institutions in Italy, the Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Hospital and the University of Milan. ​ Newronika comprises a multidisciplinary team formed from Neuroscience research groups and involves scientists with expertise in neurophysiology, neurology, biomedical engineering, neuropsychology, bioinformatics, and biotechnologies.
• Bio4Dreams — Il primo incubatore italiano certificato di startup innovative in fase very early stage, a capitale totalmente privato, dedicato alle Scienze della Vita.

Portfolio highlights

• CellPly — Cellply is a life-science company focused on developing next-generation analytical tools enabling a deep characterization of cancer immunotherapies, cell therapies and cell-based biotherapeutics. The company aims to support the development of novel cancer immunotherapies by accelerating R&D, automating the quality control and advancing theability to monitor the clinical response to these treatments.Through the use of proprietary microfluidic technologies with Co-Culture Array technology, highly-automated analytical instruments and AI-powered image and data analytics, Cellply products define the function of the immune system one cell at a time, combining functional data with other multiplex data and providing unprecedented single-cell analytical solutions.
• GreenBone Ortho — GreenBone Ortho was founded in Faenzato offer advanced and innovative solutions in the field of orthopaedics and bone regeneration, using the Rattan wood.
• Angiodroid — Angiodroid srl, a medical technology company, focuses on hemodynamics, vascular surgery, and interventional radiology. It offers an automatic injection system for carbon dioxide angiography. Its products include carbon dioxide injector that is used as a contrast medium for pheriperal interventional angiography; and a single use kit, which iscomposed of French catheters and a custom connection line. The company is based in San Lazzaro di Savena, Italy.

Portfolio highlights

• Valmet — Valmet is the leading global developer and supplier of technologies, automation and services for the pulp, paper and energy industries.
• CTP — CTP NV is a real estate company that owns and develops industrial and logistics parks.
• Cofina Ivory — Cofina Ivory is a savings and credit institution that operates in the sector of mesofinance.

Portfolio highlights

• Talyn Air — Inspired by two-stage rockets, our innovative eVTOL uses two flight vehicles to transform flight. Fixed-wing performance with VTOL capabilities.
• BillionToOne — We are a team at the forefront of disease detection focused on moving Prenatal Screening and Liquid Biopsy forward.
• CaSRevolution — A novel disease-modifying approach against neurodegeneration

Portfolio highlights

• Apron — Sort, pay and reconcile your invoices in seconds.
• Worldover — Cosmetic compliance made simple
• Class Companion — Class Companion is a new AI technology that allows professors to provide students with immediate, individualized feedback.

Portfolio highlights

• Piantando — Piantando sells plants connected to initiatives for the preservation of the planet engaged in the following areas: land, water, climate, biodiversity and local communities. Each plant is equivalent to a transparent and unique contribution, destined to an initiative certified by our Value Chain. Everyone become ambassadors of a new way of livinggreen and understanding their commitment to the planet.
• FrescoFrigo - Healthy food close to you — FrescoFRIGO is a smart fridge with fresh and quality products designed for the needs of worker. Improve everyday lifestyle, through automated proximity selling of good, fresh and healthy product, innovating technology and user experience.
• The Nemesis — The Nemesis is the Metaverse for the mass market: virtual worlds, adventures, gaming Play & Earn and amazing experiences.

Portfolio highlights

• Freatic — We bridge the gap between individuals with untapped knowledge and actors who can take advantage of these opportunities.
• Eden Bio — Eden Bio is a biotech using machine learning to guide the genetic engineering of microorganism strain optimisation, improving protein yield.
• CaSRevolution — A novel disease-modifying approach against neurodegeneration

Portfolio highlights

• Diamante — Diamante is a company that develops and manufactures autoimmune disease diagnosis devices using nanomaterials. It exploits plants as bioreactors for the sustainable production of nanoparticles based on modified plant viruses that are used in developing new tools. Diamante was founded in 2016 and is headquartered in Verona, Italy.
• FUTURELY — FUTURELY is a platform which will help to choose university.

Portfolio highlights

• Immigo — Natural expressions, used in real conversations. Get real-time feedback from our top teachers.
• Derisk — Derisk is a crypto custody infra and leverages Multi-Party Computation (MPC) cryptography.
• Sunlight — Sunlight is an API to change the card-on-file with apps and subscription services. Fintechs use Sunlight to automatically make their cards top-of-wallet as soon as they're issued.

Portfolio highlights

• DAXOR — DAXOR Corporation is an innovative medical instrumentation and biotechnology company. DAXOR designed and developed the BVA-100 Blood Volume Analyzer. It is the first instrument approved by the FDA to provide rapid direct measurement of a patient's true blood volume. We believe that the BVA-100 Blood Volume Analyzer has the potential totransform therapy in a broad range of surgical and medical conditions. It is our goal, working in conjunction with hospitals and clinics, to achieve that possibility.The BVA-100 is a semi-automated Blood Volume Analyzer. It is used in conjunction with a single use diagnostic kit. It is the first FDA-approved instrument to provide rapid direct measurement of a patient's blood volume.
• Preteckt — Preteckt offers cloud-based vehicle prognostics powered by AI to support all fleet vehicle types while delivering the world's highest precision repair plans. Get to the root cause 40% faster.
• Branch Technology — Patented 3D-printed fabrication technology combining additive manufacturing, prefabrication, and digital technology at construction scale, with true design freedom.

Portfolio highlights

• Diamante — Diamante is a company that develops and manufactures autoimmune disease diagnosis devices using nanomaterials. It exploits plants as bioreactors for the sustainable production of nanoparticles based on modified plant viruses that are used in developing new tools. Diamante was founded in 2016 and is headquartered in Verona, Italy.
• Terrific — We bring Brands & Influencers together to recreate the online shopping experience by empowering the story of your brand.

Portfolio highlights

• Diamante — Diamante is a company that develops and manufactures autoimmune disease diagnosis devices using nanomaterials. It exploits plants as bioreactors for the sustainable production of nanoparticles based on modified plant viruses that are used in developing new tools. Diamante was founded in 2016 and is headquartered in Verona, Italy.

Portfolio highlights

• Relicta — Relicta solution is a water-soluble bioplastic material obtained from fish processing waste and suitable for packaging solutions.
• QuantaBrain — QuantaBrain purpose is to accelerate the diagnosis of psychiatric and neurodevelopmental diseases by applying artificial intelligence.

Portfolio highlights

• Ossio — OSSIO is an orthopedic fixation company committed to transforming the orthopedic experience for patients, physicians, and payors. Their vision is to provide the first credible replacement to metal implants in the $10B+ orthopedic fixation market (screws, pins, plates) with an Intelligent Bone Regeneration Technology. OSSIOfiber represents abreakthrough material platform for orthopedic and podiatric surgeons who seek a more biologically friendly way to restore patient stability and mobility with nothing permanent left behind.Founded in 2014, OSSIO began as the culmination of years of biomechanical research and a vision for the possibility of better bone healing. The technological basis of OSSIOfiber™ was developed and would lay the groundwork for ushering in a new breakthrough category of non-permanent fixation, “Bio-Integratives” hardware that has both desired strength AND bio-friendliness. Hardware that has the mechanical strength for easy insertion and secure fixation, while enabling the body to regrow bone, incorporating and replacing the implant (without the adverse inflammation and weakness often seen in “bio-resorbables and other “bio-composites”), has remained elusive to the industry until now.
• Nalu Medical — Nalu Medical is an early-stage company that develops a range of medical devices. Their vision to modernize and improve the technology in medical devices, thus improving the lives of people.The Nalu neurostimulation system is a battery-free, micro-implantable pulse generator (iPG) currently cleared by the FDA for both Spinal Cord Stimulation (SCS)and Peripheral Nerve Stimulation (PNS) for mitigating chronic pain. The company was founded in 2014 and is based in Carlsbad, California.
• Neurolens — 2/3 of patients experience the symptoms of eye misalignment, but relief is in sight with Neurolens using the NMD2 and Neurolenses with Contoured Prism.

Portfolio highlights

• Adamas Biotech — More than a decade of basic research in the field of botanical function-specific antioxidants. The nutraceutical solutions proposed to stem from a patented protected technology.

Portfolio highlights

• Diamante — Diamante is a company that develops and manufactures autoimmune disease diagnosis devices using nanomaterials. It exploits plants as bioreactors for the sustainable production of nanoparticles based on modified plant viruses that are used in developing new tools. Diamante was founded in 2016 and is headquartered in Verona, Italy.

Portfolio highlights

• Endostart — Endostart development and manufacturing of a new generation medical devices for gastrointestinal endoscopy.

Portfolio highlights

• Fincantieri — Fincantieri is one of the shipbuilding groups and number one by diversification and innovation. It is leader in cruise ship design and construction and a reference player in all high-tech shipbuilding industry’s sectors, from naval to offshore vessels, from high-complexity special vessels and ferries to mega-yachts, ship repairs and conversions,systems and components production and after-sales services.
• Goglio Group — Goglio Group produces full trademark food packaging.
• Generalfinance — Generalfinance is a financial management agency that provides flexible services designed to address the company's debt issues.

Portfolio highlights

• Battistella — Battistella sells lumber, pine chips, sawdust, and pine logs. They serve both domestic and foreign markets. It exports its products worldwide. They engage in continuous recycling, which gives them the experience they need to satisfy the customs regulations of the various nations where they do business. They use the sawn pine wood that they processto make furniture and packaging.
• Selene — Selene produces FFS tubulars, FFS films, preformed bags, stretch hoods, and technical films for industrial applications.
• Goglio Group — Goglio Group produces full trademark food packaging.

Portfolio highlights

• DiogenX — We incorporated DiogenX with the objective to provide new therapeutic solutions for diabetic patients. With Patrick Collombat and the team, we are focused on developing a first-in-class regenerative treatment for type 1 diabetes. Benjamin Charles CEO See the team News See more Our Work OUR APPROACH ABOUT DIABETES
• Inversago Pharma — Inversago Pharma is a preclinical-stage, biotech company specialized in the development of new therapies focusing on CB1 blockade, based on first-in-class, peripherally-acting, CB1 inverse agonists.
• Code Biotherapeutics — Code Biotherapeutics is an emerging next-generation gene therapy company pioneering the development of targeted non-viral gene therapies to treat serious and life-threatening genetic diseases not well served by other gene therapy technologies.

Portfolio highlights

• Sunvigo — Sunvigo provides you with cheap solar power from your roof and real green power from the grid.
• GFBiochemicals — GFBiochemicals is the only company to produce levulinic acid at commercial scale directly from biomass.In 2008, a group of biobased chemical experts saw the significant potential of levulinic acid to replace petroleum-based products across a range of market sectors. GFBiochemicals was founded to develop the production technology needed for thisrevolution in chemicals and biofuels.GFBiochemicals demonstrated these breakthrough technologies in the Caserta plant, in partnership with the University of Pisa and the Polytechnic University of Milan. This commercial-scale plant was retrofitted with new conversion, recovery and purification technology.

Portfolio highlights

• Quisto — On Quisto, Ho.Re.Ca. retailers can find the best suppliers in their area and purchase 24/7 whatever they need for their business --> www.quisto.it
• CaSRevolution — A novel disease-modifying approach against neurodegeneration
• Viceversa — Viceversa provides capital to European digital businesses to support companies in sustainable and ethical growth. The company was founded in 2021 and has locations in Milan and Dublin.

Portfolio highlights

• Adamas Biotech — More than a decade of basic research in the field of botanical function-specific antioxidants. The nutraceutical solutions proposed to stem from a patented protected technology.

Portfolio highlights

• Leva Clinic — Leva Clinic offers health care services for people with chronic pain. Their medical services include back pain, cancer pain, endometriosis, facial pain, fibromyalgia, joint pain, knee pain, multiple sclerosis, sciatica, and so on.
• Octarine Bio — Octarine Bio is a synthetic biology company that produces superior cannabinoids for the pharmaceutical industry.
• Herbolea Biotech — Unique bio-processing technologies NATURAL, SOLVENT-LESS Botanical extraction Learn more

Portfolio highlights

• Erydel — Based in Urbino, EryDel has developed and patented a technology for drug delivery of pharmacological agents through erythrocytes (red blood cells). This process allow to easily load red blood cells with drugs, proteins, contrasting agents for diagnostic purposes, nanoparticles etc. that can be progressively released into the patient body thusallowing an increased efficacy of the therapy and a reduction of collateral effects. The benefit is extremely significant particularly for chronic pathologies that requires continuous daily treatments for patients which could be substituted by monthly transfusion of blood loaded with specific therapeutic agents. Currently, the solution has been tested by several patients for the treatment of Inflammatory Bowel Diseases (IBDs) such as ulcer colitis and Crohn disease. The company can provide a complete support for the drug delivery process including a specific device for the erythrocytes loading ("Red Cell Loader"), and disposable kits.

Portfolio highlights

• Vara — Vara develops a breast cancer screening platform powered by AI for radiologists, allowing them to focus on finding cancer early. While we provide. Vara also provides remote mammography reading services to those that lack the radiologists. Vara's mission is to make affordable diagnostics available all over the world by designing machinelearning-powered workflows that users love to work with.
• Oculis — The Oculis drug delivery platform consists of a novel technique to facilitate drug absorption to both anterior and posterior parts of the eye. The advantage is a drug delivery system where diseases of the posterior part of the eye can be treated with a simple topical application. The Oculis drug delivery platform allows diseases such as DME(diabetic macular edema) at the posterior part of the eye to be treated with a non-invasive topical application. Furthermore, the technique has been demonstrated to allow diseases at the anterior part of the eye to be treated with a reduced number of topical applications compared to conventional eye-drops.
• Xeltis — Xeltis is pioneering a restorative approach in cardiovascular therapy.

Portfolio highlights

• AstriVax — AstriVax aims for initial clinical validation of the platform technology, to develop a broad vaccination pipeline.
• Precirix — Developing radio-immunotherapeutic drugs for cancer patients.
• Sibylla Biotech — Sibylla Biotech developed small molecule folding interfering degraders (FIDs) that can address a range of therapeutic areas.

Portfolio highlights

• CaSRevolution — A novel disease-modifying approach against neurodegeneration

Portfolio highlights

• Perfuze — Perfuze was founded in 2018 by Wayne Allen and Liam Mullins. Perfuze is located within Galway City in the West of Ireland. The founders have over 30 years combined medtech experience within start-up and large corporations.Perfuze is developing innovative medical technology to treat acute ischemic stroke.Perfuze is developing innovative cathetertechnology to treat acute ischemic stroke. Their technology is intended to provide superior clinical outcomes in shorter procedural times; resulting in safe, cost-effective therapy. Perfuze was founded in 2018 by Wayne Allen and Liam Mullins. The founders have over 30 years combined medtech experience within start-up and large corporations. Perfuze is currently located in the Business Innovation Centre on the campus of the National University of Ireland, Galway, and is in the process of relocating to the IDA Business Park in Dangan, Galway.
• Sibylla Biotech — Sibylla Biotech developed small molecule folding interfering degraders (FIDs) that can address a range of therapeutic areas.
• Storm Therapeutics — Targeting pathways that modify RNA to deliver novel cancer therapeutics.

Portfolio highlights

• Ecopol — The Ecopol's PVA water-soluble film technology is the world leading solution in packaging applications, such as detergents, agrochemicals, etc.
• Finapp — Finapp is an innovative startup that produces a new generation of CRNS probes that allow measuring the water content. Water in the ground, then soil moisture, water out of the ground, then in the biomass, water in the snow, then snow water equivalent. The applications are really many, such as the research of water losses along aqueducts,hydrological and hydraulic modeling, estimates of hydroelectric energy but mainly agricultural ones.
• Generalfinance — Generalfinance is a financial management agency that provides flexible services designed to address the company's debt issues.