Top 35 Health Care Startup Investors in South Africa (May 2026)

Portfolio highlights

• Lengo — Lengo is an AI based intelligence platform that offers a large database on consumer goods for companies in the FMCG sector.
• Zanifu — The zanifu platform, allows small retailers in Sub Saharan Africa, to procure inventory from their suppliers & pay later.
• Fixit45 — Your best ever automobile service experience awaits you.

Portfolio highlights

• Talk360 — Talk360 is an easy-to-use calling app that helps people make affordable international calls to any mobile and landline number. They believe that reliable communication and digital services must be affordable and accessible to everyone, regardless of someone's background. Especially people in emerging countries in Africa, who often need theseservices the most, do not always have the necessary banking possibilities. To bridge this distance, Talk360 will launch the world's first single checkout platform for Africa. This platform will combine all locally available payment methods and currencies across Africa, together with over 1.25 million cash points of sales, and will eventually be available to other companies as well. This means that 500 million Africans will be able to purchase digital services they never had access to before.
• FinAccess — FinAccess is a banking software for microfinance organisations.
• Right Now Response — Your go-to for expert breakdown assistance. Our dedicated team ensures you're back on the road swiftly and safely. Contact us for reliable support today!

Portfolio highlights

• Inseco — Inseco is an IT company that specializes in management solutions, ERP, CRM, GED, HR, and business solutions.
• SweepSouth — Book a home cleaning online from your mobile, tablet or computer. SweepSouth connects you with a cleaner in minutes. Cleaners are experienced, reliable, efficient and insured.
• Inseco — Sustainable insect protein producers, converting organic by-products into nutritious protein. This high in protein product is used in animal feed, pet food, crop production, cosmetics and pharmaceuticals.

Portfolio highlights

• Pison — Pison is a human performance company optimizing cognitive and physiological capability through gesture control. It's a full-stack solution combine hardware, software, machine learning, and UX for AR industries and drones. Investors and partners include Special Forces, Air Force, Harris, First Round DRF, MIT, Draper, and NASA.
• Vesper — Vesper is an electrical and electronic manufacturing company that specializes in microphones, piezoelectric, and audio. The company is driven by a mission is to deliver voice-powered products to every market, around the world. Vesper was founded in 2009 and headquartered in Boston, Massachusetts.
• Medrhythms — Pioneering Next-Generation Digital Therapeutics to Improve Walking  

Portfolio highlights

• Laborhack — LaborHack offers a select network of tested and certified carpenters, plumbers, electricians, masons, welders, and other tradespeople. It provides cleaning, plumbing, electrical, and HVAC services.
• Trade Lenda — With Trade Lenda, get quick finance in Nigeria without collateral.
• Feather Africa — Feather Africa provides money transaction services, such as enabling users to send and receive money from anyone using the application. It offers withdrawals of cash without ATM cards by sending money to the nearest cash vendors.

Portfolio highlights

• Synatic — Synatic is a unified platform that enables your business to integrate and automate systems and services without sacrificing enterprise features and security.
• MFS Africa — MFS Africa is the largest mobile money inter-operability hub in Africa, which connects mobile network operators across the continent through a single API. In addition to mobile remittance services, the MFS Africa API enables merchant payment, bulk payment, bank-to-wallet transfers, and an array of other cross border digital payments services.
• Peach Payments — Get Peach as your Payment Gateway and Grow your ecommerce. Process online payments with Visa, Mastercard, Debit Orders, EFT payments, and subscriptions. Plugins for Wix, Shopify, WooCommerce.

Portfolio highlights

• Talk360 — Talk360 is an easy-to-use calling app that helps people make affordable international calls to any mobile and landline number. They believe that reliable communication and digital services must be affordable and accessible to everyone, regardless of someone's background. Especially people in emerging countries in Africa, who often need theseservices the most, do not always have the necessary banking possibilities. To bridge this distance, Talk360 will launch the world's first single checkout platform for Africa. This platform will combine all locally available payment methods and currencies across Africa, together with over 1.25 million cash points of sales, and will eventually be available to other companies as well. This means that 500 million Africans will be able to purchase digital services they never had access to before.
• SweepSouth — Book a home cleaning online from your mobile, tablet or computer. SweepSouth connects you with a cleaner in minutes. Cleaners are experienced, reliable, efficient and insured.
• Yebo Fresh — Powering South Africa's Township Economy.

Portfolio highlights

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• Koa Academy — Koa Academy is on the cutting edge of online schooling in South Africa! We offer small classes, quality educators, and individualized, engaged online learning.
• Brown and Ayo — Brown & Ayo brings you a range of hair extensions created to mimic our natural hair textures. We pride ourselves in bringing you both trendy and well-loved products. All our products are ethically sourced and sustainably manufactured.

Portfolio highlights

• Mobiz — Supercharge your SMS marketing with dynamic, high-converting landing pages sent directly into the hands of your customers.
• Sendmarc — Stop cyber criminals from sending emails using your domain and protect your customers, suppliers and employees from cyber attacks with DMARC Security.
• MFS Africa — MFS Africa is the largest mobile money inter-operability hub in Africa, which connects mobile network operators across the continent through a single API. In addition to mobile remittance services, the MFS Africa API enables merchant payment, bulk payment, bank-to-wallet transfers, and an array of other cross border digital payments services.

Portfolio highlights

• Sendmarc — Stop cyber criminals from sending emails using your domain and protect your customers, suppliers and employees from cyber attacks with DMARC Security.
• Leta — Leta Technology is a software development company that creates supply chain and logistics software to enable the efficient and automated movement of goods.
• Numida — Growing African small businesses with affordable, convenient, and fair credit.

Portfolio highlights

• Jobox — Jobox is a student recruitment platform, built to connect employers, students and graduate career offices. Our focus is to improve graduate employability by ensuring all students have the skills they need to enter, stay in, and progress in the world of work.Jobox’s ecosystem provides employers with access to the best diverse & youthfultalent, students with more employment opportunities and universities with data-driven insights aimed at driving graduate employability forward.
• Contro — Contro is an online prescription and delivery service for sexual health and confidence products such as birth control and erectile dysfunction treatment. Contro, through its secure digital platform, allows individuals to take control of their personal wellness by offering a convenient, affordable and discreet subscription service. Offering a cancelanytime policy, Contro makes it easier than ever to obtain sexual health products in South Africa.

Portfolio highlights

• hearX Group — Digital audiology technology to screen, diagnose & treat hearing loss globally. Award-winning solutions for more efficient & cost-effective hearing care.

Portfolio highlights

• RecoMed — Find the best doctors and dentists. Search by location or by speciality, and find the right doctor for you.
• Digital Cabinet — Digital Cabinet makes your business paperless. Security is the topmost priority for the Digital Cabinet, so save time and money with the Digital Cabinet.

Portfolio highlights

• I-G3N — I-G3N is a South African developer of lithium-ion batteries. The company’s core market is on stationary storage in conjunction with Solar PV and focuses on superior products and on the incorporation of the latest technologies to battery functionality. One of the key focus areas is on exporting to the SADC region and the rest of Africa, asextraordinary opportunities exist on the rest of the continent, especially in the development of mini and micro-grids to impact development.
• Pineapple — In short, Pineapple see the traditional insurance model, user journey and products as lacking and set out to remedy these by doing the following: 1) Changing the business model to align incentives, show people how premiums are used and award members leftover premium back 2) Making insuring as easy as snapping a picture where AI does the rest andcover is issued in under 60 seconds 3) Allowing per-item insurance and new product innovation to address cover not currently offered or accessible to manyPineapple launched in South Africa in 2018 with their "My Stuff" per-item insurance and have since launched their auto offering "My Ride". They have also partnered with Travelers in the US and have white-labeled their platform in the US.
• Aviro Health — We believe that empowering and supporting people to manage their own health benefits everybody.We built the Aviro Pocket Clinic to support self-care and provide access to services. We give people what they need to perform important health checks like regular HIV self-testing and connect them to experts and services who can offer hands-on and supported care when needed.

Portfolio highlights

• RecoMed — Find the best doctors and dentists. Search by location or by speciality, and find the right doctor for you.

Portfolio highlights

• LIQID Medical — LIQID Medical is a medical equipment manufacturing organization focusing on the development of technological glaucoma treatment devices.

Portfolio highlights

• Contro — Contro is an online prescription and delivery service for sexual health and confidence products such as birth control and erectile dysfunction treatment. Contro, through its secure digital platform, allows individuals to take control of their personal wellness by offering a convenient, affordable and discreet subscription service. Offering a cancelanytime policy, Contro makes it easier than ever to obtain sexual health products in South Africa.

Portfolio highlights

• Djamo — Djamo is a Provider of financial applications to allow customers to use their cards with zero fees in a wide range of services.
• Jumba — Jumba is a construction technology platform that streamlines B2B construction material purchase and financing.
• Yebo Fresh — Powering South Africa's Township Economy.

Portfolio highlights

• Contro — Contro is an online prescription and delivery service for sexual health and confidence products such as birth control and erectile dysfunction treatment. Contro, through its secure digital platform, allows individuals to take control of their personal wellness by offering a convenient, affordable and discreet subscription service. Offering a cancelanytime policy, Contro makes it easier than ever to obtain sexual health products in South Africa.

Portfolio highlights

• STRM.BIO — STRM.BIO specializes in the fields of biotechnology and life science.
• Scentian Bio — Scentian Bio operates as a platform that provides ultimate sensing solution.
• AN2 Therapeutics — AN2 Therapeutics, Inc. is a California-based global health biopharmaceutical company focused on modern biomedical and drug development expertise to provide transformational medicines for patients suffering from infectious diseases. The company was founded in 2017 and is headquartered in Menlo Park, California, United States.

Portfolio highlights

• BusyMed — BusyMed connects independent local pharmacists to their communities using the BusyMed App. Get your medication delivered to your door in 60 minutes. Shop. Pay. Delivered.

Portfolio highlights

• Blusink — Blusink is an ocean-based carbon removals company.
• EF Polymer — EF Polymer Private Limited providing 100% Organic and fully Biodegradable Super Absorbent Polymer cum Fertilizer to reduce Water and Fertilizer requirement for your plant. Let's grow organically.
• MORPHEUS — Development of Nose To Brain Drug Delivery System (DDS)

Portfolio highlights

• Tactyc — Tactyc is an easy-to-use portfolio construction, forecasting and management software for venture funds.
• Zoie Health — Zoie is a digital health firm for women that provides family planning, fertility, and maternity care services.
• Money Fellows — MoneyFellows digitizes the ROSCA model, enabling group lending and savings.

Portfolio highlights

• Syscap — Syscap is a financial technology company that offers cutting-edge solutions to financial institutions to have a better administration and management of their funding sources. It connects the leaders of financial and real estate institutions with their funders. For institutions, the company ensures the optimization of their funding source managementprocesses, but also the strengthening of the relationship with their funders. To funders, Syscap guarantees the transparency and timely monitoring of its funds for the safety and growth of its resources.
• Godochurch — GoDoChurch is a cloud-based church administration software which is designed to assist Christian churches and ministries with managing members, Sunday services, events, communications, and more. The system is made up of a base package, covering messaging, news, ministries, lists, church roles, services, events, and growth paths, with additionalmodules for managing follow-ups, groups, and Kids church.
• Ikeja Wireless — Welcome to your Ikeja. We are a home-grown tech company that builds services enabling affordable internet access to Ekasi. We may have coverage in your area!

Portfolio highlights

• FERNRIDE — Fernride enables automated, sustainable logistics by combining the skills of remote drivers with autonomous technologies.
• Valutico — Valutico is the world‘s leading provider of web-based company valuation tools.Started in 2014 by a team of enthusiastic Corporate Finance professionals and web developers, the concept was born out of frustration with the status-quo in Corporate Finance practice: That professional company valuations used to be the domain of only the mostsophisticated of investors.At Valutico, it has been their mission from the outset to offer cutting-edge valuation tools to a much wider audience. Today they empower everybody to perform company valuations that meet and exceed the standards of even the leading investment banks and advisory firms.The company today is headquartered in Vienna/Austria and has an additional office in Frankfurt/Germany.
• Ohana — Ohana helps you to protect your child in the digital world. Limit screentime, get insights & guidance, block apps & websites and filter inappropriate content.

Portfolio highlights

• MX Labs — Allow your user to comprehensively monitor their vital signs. Check wellbeing, prevent misdiagnosis, and motivate lifestyle changes thanks to Shen.AI.
• Saludtools — Saludtools is a digital platform that improves access, quality and reliability of medical services for thousands of patients in Latin America. Our innovative and friendly technology breaks the barriers that prevent a better medical attention. We are about making outstanding healthcare accessible for everyone.
• VitruvianMD — VitruvianMD combines biomedical engineering and state-of-the-art artificial intelligence (AI) to deliver affordable, high-accuracy diagnostic tools for medical laboratories, with a particular focus on servicing emerging markets.

Portfolio highlights

• Jobox — Jobox is a student recruitment platform, built to connect employers, students and graduate career offices. Our focus is to improve graduate employability by ensuring all students have the skills they need to enter, stay in, and progress in the world of work.Jobox’s ecosystem provides employers with access to the best diverse & youthfultalent, students with more employment opportunities and universities with data-driven insights aimed at driving graduate employability forward.
• Aviro Health — We believe that empowering and supporting people to manage their own health benefits everybody.We built the Aviro Pocket Clinic to support self-care and provide access to services. We give people what they need to perform important health checks like regular HIV self-testing and connect them to experts and services who can offer hands-on and supported care when needed.
• Ownedby Technologies — Ownedby is an interactive asset management solution for business and household assets, focused on appliances and devices, giving these unique identity that is traceable online, yet linked to and controlled by owners.

Portfolio highlights

• 3X4Genetics — The future of healthcare is personalized. Build a more successful practice and transform more lives using the power of DNA-driven health recommendations, through DNA & Genetic Testing!
• Lipidio Pharmaceuticals — Lipidio Pharmaceuticals is a healthcare company that focuses on advancing a molecule to treat diseases associated with excess body fat. It includes non-alcoholic steatohepatitis, Prader-Willi syndrome, and antipsychotic drug-induced weight gain. The company was founded in 2018 and headquartered in San Diego, California.
• SEngine Precision Medicine — The Search Engine For Identifying Personalized Cancer Treatments.

Portfolio highlights

• Octiv — Octiv is a well-known platform for gym management software.
• wamly — Streamline your hiring process and save 70% of your hiring hours with Wamly's our one-way video interview software.
• VoxCroft — VoxCroft is making the world a better, safer place with population-centric intelligence.

Portfolio highlights

• IQM Quantum Computers — IQM is the leading European quantum hardware company in superconducting circuits. We build quantum computers
• Kena Health — Talk to a nurse, doctor or mental health professional on your smartphone with the Kena Health App. Affordable primary healthcare for South Africans. Download Now.

Portfolio highlights

• Ello — Ello is an app-based reading coach that listens to your child read from real books, teaches and motivates them, and transforms them into enthusiastic readers.
• Brine.fi — The best onchain spot trading crypto exchange
• Automat AI — Robotic process automation for Chrome using GPT3 guided Computer Vision

Portfolio highlights

• FitKey — FitKey is about helping you find and manage the fitness life that makes you happy, through discovering new classes, studios, and fitness activities. With easy online and mobile booking, FitKey keeps your routine interesting.
• TaxTim — Originally funded by Google in 2011, TaxTim is Africa's answer to Making Tax Easy. Answer simple questions one-by-one, in a friendly automated chat, and your tax return is done in minutes. TaxTim has 40% market share of the tax base in South Africa (~4.5m), and has deployed localised versions in Namibia and Nigeria as JVs with PwC previously.TaxTim is integrated with the local revenue service (SARS) for instant electronic tax submissions, and partners with some of SA's largest consumer brands - Airbnb, Momentum, Sanlam, Old Mutual, FNB eBucks - to provide tax services for free or at discount. TaxTim has several business models including B2C, B2B and B2B2C. TaxTim is a compelling and popular consumer brand, with a fully-developed, profitable broker/financial product leads ecosystem.
• Ekaya.com — Ekaya exists to make renting simpler, safer and more connected - for everyone.

Portfolio highlights

• Quinn Residences — Quinn Residences offers newly-built houses for rent located in the best neighborhoods with professional management, modern amenities and fantastic community perks for a maintenance-free lifestyle.
• Ribbon Communications — Ribbon offers innovative IP and optical networking solutions and cloud-to-edge communications solutions.
• Polsky Center for Entrepreneurship and Innovation — The Polsky Center for Entrepreneurship and Innovation at the University of Chicago runs two programs that invests in UChicago-affiliated teams: the Edward L. Kaplan, '71, New Venture Challenge (NVC) program and the Polsky Center Accelerator Program. For more information and details on how to apply, please visit: http://chicagonvc.comor http://polskycenter.com/accelerator/

Portfolio highlights

• Kena Health — Talk to a nurse, doctor or mental health professional on your smartphone with the Kena Health App. Affordable primary healthcare for South Africans. Download Now.

Portfolio highlights

• Ziada — Ziada is a mobile application that connects you to service providers near you and vice versa. Download Ziada today from the Google Playstore to start experiencing convenience.
• AgroCenta — AgroCenta is an online platform that connects the smallholder farmer in the staple food (rice, maize, millet and soybean) value chain to a wider online market to trade
• HealthDart — Consult with a doctor, nurse or pharmacist, order medicines or get health advice - at a price you can afford